Gold- and silver-mediated cycloisomerizations of N-propargylamides.


Substituted N-propargylamides have proven to be valuable substrates for alkyne-activated cycloisomerization reactions. N-Tosyl- N'-propargylurea underwent reaction with AuCl 3 to give the corresponding dihydroimidazolone, while N-propargyl-3-oxobutanamides and esters were used to construct furanyl fused pyrrolidinones and dihydrofuranones via Ag(I)-mediated… (More)
DOI: 10.1021/ol801847j


Cite this paper

@article{Verniest2008GoldAS, title={Gold- and silver-mediated cycloisomerizations of N-propargylamides.}, author={Guido Verniest and Albert Padwa}, journal={Organic letters}, year={2008}, volume={10 19}, pages={4379-82} }