Gold(III) compound is a novel chemocytotoxic agent for hepatocellular carcinoma.

@article{Lum2006GoldIIICI,
  title={Gold(III) compound is a novel chemocytotoxic agent for hepatocellular carcinoma.},
  author={Ching Tung Lum and Zhen Fan Yang and Hoi Yee Gloria Li and Raymond Wai-Yin Sun and Sheung Tat Fan and Ronnie Tung-ping Poon and Marie Chia Mi Lin and Chi-ming Che and Hsiang Fu Kung},
  journal={International journal of cancer},
  year={2006},
  volume={118 6},
  pages={1527-38}
}
Recently, a series of gold(III) meso-tetraarylporphyrins that are stable against demetallation in physiological conditions have been synthesized. In the present study, the antitumor effects of one of these compounds, gold(III) meso-tetraarylporphyrin 1a (gold-1a) was investigated in an orthotopic rat hepatocellular carcinoma (HCC) model as well as using a HCC cell line. The rat HCC model was induced by injection of rat hepatoma cells, McA-RH7777, into the left lobe of the liver. Seven days… CONTINUE READING