Goiter in a Newborn Exposed to Lithium in Utero

@article{Frassetto2002GoiterIA,
  title={Goiter in a Newborn Exposed to Lithium in Utero},
  author={Florence Frassetto and Florence Tourneur Martel and Claude E Barjhoux and C{\'e}line Villier and Brigitte Le Bot and Françoise Vincent},
  journal={Annals of Pharmacotherapy},
  year={2002},
  volume={36},
  pages={1745 - 1748}
}
OBJECTIVE: To report a case of neonatal goiter and biological hypothyroidism in a newborn exposed to lithium in utero resulting from therapy given to the mother before and during her pregnancy. CASE SUMMARY: A male neonate, born at 37 weeks' gestation, presented with a goiter without other signs of hypothyroidism. His serum thyroid-stimulating hormone concentration was high and unbound tetrathyroxine concentration was low, indicating that chronic exposure to lithium was present. Oral thyroxine… 
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38 Citations
Background Citations
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38 Citations

Lithium during pregnancy and after delivery: a review
TLDR
An up-to-date overview of the literature on lithium use during pregnancy and after delivery leading to clinical recommendations is provided.
Neonatal thyroid-stimulating hormone level is influenced by neonatal, maternal, and pregnancy factors.
Mild iodine deficiency in pregnancy in Europe and its consequences for cognitive and psychomotor development of children: a review.
The pharmacology of bipolar disorder during pregnancy and breastfeeding
TLDR
Treating bipolar disorder in women during reproduction presents a significant challenge to the physician, and strategies are available that minimise the risk to the fetus and infant whilst still providing effective prophylaxis againstipolar disorder in the mother.
[The treatment of bipolar disorder during pregnancy and the postpartum period].
TLDR
Each medication's effects on organ dysgenesis, neonatal toxicity, and neurobehavioral development, and their associated adverse events during pregnancy and the postpartum period are discussed, with a focus on the emerging literature.
Protocol of the PSYCHOTSH study: association between neonatal thyroid stimulating hormone concentration and intellectual, psychomotor and psychosocial development at 4–5 year of age: a retrospective cohort study
TLDR
The results could lead to a reassessment of the recommended cut-off levels of 5 > mU/L used for monitoring iodine status of the population and the definition of new TSH cut-offs for determination of the severity of iodine status and for practical use in data reporting by neonatal screening centres.
The safety of medications for the treatment of bipolar disorder during pregnancy and the puerperium.
TLDR
There have been an insufficient number of first trimester exposures to the newer anticonvulsant mood stabilisers, lamotrigine and oxcarbazepine, to determine whether there is a safety advantage in switching to these agents.
Lithium Use and Non-use for Pregnant and Postpartum Women with Bipolar Disorder
TLDR
Data regarding lithium use during the peripartum and management recommendations for general psychiatric clinicians are reviewed and recent studies indicate that lithium use in pregnancy is associated with either no increased malformations risk or a small increase in risk for cardiac malformation.
Lithium placental passage and obstetrical outcome: implications for clinical management during late pregnancy.
TLDR
Lithium completely equilibrates across the placenta, and higher lithium concentrations at delivery are associated with more perinatal complications, and lithium concentrations can be reduced by brief suspension of therapy proximate to delivery.
Prophylactic treatment of bipolar disorder in pregnancy and breastfeeding: focus on emerging mood stabilizers.
  • S. Gentile
  • Medicine, Psychology
    Bipolar disorders
  • 2006
TLDR
This review compares information from the literature on the safety of lamotrigine, oxcarbazepine, risperidone, olanzapine, and quetiapine to the safety data on classic mood stabilizers during pregnancy and the postpartum period to suggest thatUntreated pregnant bipolar women are at an increased risk of poor obstetrical outcomes and relapse of affective symptoms.
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