Goiter in a Newborn Exposed to Lithium in Utero
@article{Frassetto2002GoiterIA, title={Goiter in a Newborn Exposed to Lithium in Utero}, author={Florence Frassetto and Florence Tourneur Martel and Claude E Barjhoux and C{\'e}line Villier and Brigitte Le Bot and Françoise Vincent}, journal={Annals of Pharmacotherapy}, year={2002}, volume={36}, pages={1745 - 1748} }
OBJECTIVE: To report a case of neonatal goiter and biological hypothyroidism in a newborn exposed to lithium in utero resulting from therapy given to the mother before and during her pregnancy. CASE SUMMARY: A male neonate, born at 37 weeks' gestation, presented with a goiter without other signs of hypothyroidism. His serum thyroid-stimulating hormone concentration was high and unbound tetrathyroxine concentration was low, indicating that chronic exposure to lithium was present. Oral thyroxine…
38 Citations
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- 2015
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- 2013
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- 2006
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- 2006
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References
SHOWING 1-10 OF 28 REFERENCES
Three-year follow-up of borderline congenital hypothyroidism.
- Medicine, BiologyThe Journal of pediatrics
- 2000
Prospective multicentre study of pregnancy outcome after lithium exposure during first trimester
- MedicineThe Lancet
- 1992
A reevaluation of risk of in utero exposure to lithium.
- MedicineJAMA
- 1994
More recent epidemiologic data indicate that the teratogenic risk of first-trimester lithium exposure is lower than previously suggested, and the clinical management of women with bipolar disorder who have childbearing potential should be modified with this revised risk estimate.
Occurrence of Goitre during Lithium Treatment
- Medicine, BiologyBritish medical journal
- 1968
Of 330 patients given lithium for recurrent manic-depressive disorder 12 developed goitre after treatment periods of five months to two years. All the patients remained clinically euthyroid. Pressure…
Congenital hypothyroidism: etiologies, diagnosis, and management.
- Medicine, BiologyThyroid : official journal of the American Thyroid Association
- 1999
Thyroid scintigraphy, using 99mTc or 123I, is the most accurate diagnostic test to detect thyroid dysgenesis or one of the inborn errors of T4 synthesis, and may miss some cases of ectopic glands.
Thyroid disorders.
- Medicine, BiologyThe Journal of the Arkansas Medical Society
- 1984
Thyroid dysfunctions are relatively common among women of reproductive age, and can affect fertility in various ways, resulting in anovulatory cycles, high prolactin levels, and sex hormone imbalances.
Lithium administration affects gene expression of thyroid hormone receptors in rat brain.
- Biology, PsychologyLife sciences
- 1999
Endocrine disorders
- Medicine, BiologyCurrent opinion in rheumatology
- 1991
Musculoskeletal problems in chronic renal failure are common, but investigations into their pathogenesis are complicated by the coexistence of renal endocrine failure and β2-microglobulin-related amyloid deposition in long-term dialysis patients.
The Place of Lithium in Biological Psychiatry
- Psychology, Medicine
- 1980
Lithium has revolutionized the treatment of affective disorders and its prophylactic effect in depression — both the depressed phase of manic-depressive illness, and recurrent depressive disorder — though less dramatic, has been found to be significant.