Goiter in a Newborn Exposed to Lithium in Utero

@article{Frassetto2002GoiterIA,
  title={Goiter in a Newborn Exposed to Lithium in Utero},
  author={Florence Frassetto and Florence Tourneur Martel and Claude E Barjhoux and C{\'e}line Villier and B. Le Bot and Françoise Vincent},
  journal={Annals of Pharmacotherapy},
  year={2002},
  volume={36},
  pages={1745 - 1748}
}
OBJECTIVE: To report a case of neonatal goiter and biological hypothyroidism in a newborn exposed to lithium in utero resulting from therapy given to the mother before and during her pregnancy. CASE SUMMARY: A male neonate, born at 37 weeks' gestation, presented with a goiter without other signs of hypothyroidism. His serum thyroid-stimulating hormone concentration was high and unbound tetrathyroxine concentration was low, indicating that chronic exposure to lithium was present. Oral thyroxine… Expand
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Lithium during pregnancy and after delivery: a review
TLDR
An up-to-date overview of the literature on lithium use during pregnancy and after delivery leading to clinical recommendations is provided. Expand
Neonatal thyroid-stimulating hormone level is influenced by neonatal, maternal, and pregnancy factors.
TLDR
It is shown that several neonatal, maternal, and pregnancy-related determinants are influencing neonatal TSH level, and higher TSH levels were associated with lifetime smoking behavior in the mother, lower weight gain during pregnancy, and longer pregnancies. Expand
Mild iodine deficiency in pregnancy in Europe and its consequences for cognitive and psychomotor development of children: a review.
TLDR
It is difficult to establish a direct link between maternal iodine deficiency and maternal hypothyroxinaemia, but some studies suggest that iodine supplementation from the first trimester until the end of pregnancy may decrease the risk of cognitive and psychomotor developmental delay in the offspring. Expand
Neonatal Thyroid Function
TLDR
Knowing of normal thyroid function in the neonatal period and factors affecting it are critical for physicians caring for newborns. Expand
The pharmacology of bipolar disorder during pregnancy and breastfeeding
TLDR
Treating bipolar disorder in women during reproduction presents a significant challenge to the physician, and strategies are available that minimise the risk to the fetus and infant whilst still providing effective prophylaxis againstipolar disorder in the mother. Expand
[The treatment of bipolar disorder during pregnancy and the postpartum period].
TLDR
Each medication's effects on organ dysgenesis, neonatal toxicity, and neurobehavioral development, and their associated adverse events during pregnancy and the postpartum period are discussed, with a focus on the emerging literature. Expand
Protocol of the PSYCHOTSH study: association between neonatal thyroid stimulating hormone concentration and intellectual, psychomotor and psychosocial development at 4–5 year of age: a retrospective cohort study
TLDR
The results could lead to a reassessment of the recommended cut-off levels of 5 > mU/L used for monitoring iodine status of the population and the definition of new TSH cut-offs for determination of the severity of iodine status and for practical use in data reporting by neonatal screening centres. Expand
The safety of medications for the treatment of bipolar disorder during pregnancy and the puerperium.
TLDR
There have been an insufficient number of first trimester exposures to the newer anticonvulsant mood stabilisers, lamotrigine and oxcarbazepine, to determine whether there is a safety advantage in switching to these agents. Expand
Lithium Use and Non-use for Pregnant and Postpartum Women with Bipolar Disorder
TLDR
Data regarding lithium use during the peripartum and management recommendations for general psychiatric clinicians are reviewed and recent studies indicate that lithium use in pregnancy is associated with either no increased malformations risk or a small increase in risk for cardiac malformation. Expand
Lithium placental passage and obstetrical outcome: implications for clinical management during late pregnancy.
TLDR
Lithium completely equilibrates across the placenta, and higher lithium concentrations at delivery are associated with more perinatal complications, and lithium concentrations can be reduced by brief suspension of therapy proximate to delivery. Expand
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