Going viral with cancer immunotherapy

@article{Lichty2014GoingVW,
  title={Going viral with cancer immunotherapy},
  author={Brian Dennis Lichty and Caroline J. Breitbach and David Francis Stojdl and John Cameron Bell},
  journal={Nature Reviews Cancer},
  year={2014},
  volume={14},
  pages={559-567}
}
Recent clinical data have emphatically shown the capacity of our immune systems to eradicate even advanced cancers. Although oncolytic viruses (OVs) were originally designed to function as tumour-lysing therapeutics, they have now been clinically shown to initiate systemic antitumour immune responses. Cell signalling pathways that are activated and promote the growth of tumour cells also favour the growth and replication of viruses within the cancer. The ability to engineer OVs that express… CONTINUE READING
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