Going nuclear in metabolic and cardiovascular disease.

  title={Going nuclear in metabolic and cardiovascular disease.},
  author={Christopher K. Glass},
  journal={The Journal of clinical investigation},
  volume={116 3},
Estrogen receptors, PPARs, and liver X receptors are members of the nuclear receptor superfamily of ligand-dependent transcription factors that regulate diverse aspects of development and homeostasis. Recent studies of the biologic roles of these receptors and their mechanisms of action have significantly advanced our understanding of transcriptional programs that control lipid and carbohydrate metabolism, immunity and inflammation, and wound repair. These findings provide insights into the… CONTINUE READING