Going APE over ref-1.

@article{Evans2000GoingAO,
  title={Going APE over ref-1.},
  author={Alan G. R. Evans and M Limp-Foster and Mark R Kelley},
  journal={Mutation research},
  year={2000},
  volume={461 2},
  pages={83-108}
}
The DNA base excision repair (BER) pathway is responsible for the repair of cellular alkylation and oxidative DNA damage. A crucial and the second step in the BER pathway involves the cleavage of baseless sites in DNA by an AP endonuclease. The major AP endonuclease in mammalian cells is Ape1/ref-1. Ape1/ref-1 is a multifunctional protein that is not only responsible for repair of AP sites, but also functions as a reduction-oxidation (redox) factor maintaining transcription factors in an active… CONTINUE READING
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Ape1/ref-1 levels have been found to be elevated in a number of cancers such as ovarian , cervical , prostate , rhabdomyosarcomas and germ cell tumors and correlated with the radiosensitivity of cervical cancers .
Ape1/ref-1 levels have been found to be elevated in a number of cancers such as ovarian , cervical , prostate , rhabdomyosarcomas and germ cell tumors and correlated with the radiosensitivity of cervical cancers .
Ape1/ref-1 is a multifunctional protein that is not only responsible for repair of AP sites , but also functions as a reduction - oxidation ( redox ) factor maintaining transcription factors in an active reduced state .
Ape1/ref-1 is a multifunctional protein that is not only responsible for repair of AP sites , but also functions as a reduction - oxidation ( redox ) factor maintaining transcription factors in an active reduced state .
Ape1/ref-1 levels have been found to be elevated in a number of cancers such as ovarian , cervical , prostate , rhabdomyosarcomas and germ cell tumors and correlated with the radiosensitivity of cervical cancers .
Ape1/ref-1 levels have been found to be elevated in a number of cancers such as ovarian , cervical , prostate , rhabdomyosarcomas and germ cell tumors and correlated with the radiosensitivity of cervical cancers .
Ape1/ref-1 levels have been found to be elevated in a number of cancers such as ovarian , cervical , prostate , rhabdomyosarcomas and germ cell tumors and correlated with the radiosensitivity of cervical cancers .
TRANSCRIPTION FACTORGene product plays role in biological processdna binding
Ape1/ref-1 has been shown to stimulate the DNA binding activity of numerous transcription factors that are involved in cancer promotion and progression such as Fos , Jun , NF(B , PAX , HIF-1 ( , HLF and p53 .
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