Goblet cell and mucin gene abnormalities in asthma.

  title={Goblet cell and mucin gene abnormalities in asthma.},
  author={John V. Fahy},
  volume={122 6 Suppl},
  • J. Fahy
  • Published 1 December 2002
  • Biology, Medicine
  • Chest
Goblet cell hyperplasia (GCH) has been established as a pathologic characteristic of mild, moderate, and severe asthma. Abnormalities in goblet cell number are accompanied by changes in stored and secreted mucin (MUC). The functional consequences of these changes in MUC stores and secretion can contribute to the pathophysiologic mechanisms for multiple clinical abnormalities in patients with asthma, including sputum production, airway narrowing, exacerbations, and accelerated loss in lung… 

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