Go or Stop? Divergent Roles of Reelin in Radial Neuronal Migration

@article{Zhao2010GoOS,
  title={Go or Stop? Divergent Roles of Reelin in Radial Neuronal Migration},
  author={Shanting Zhao and Michael Frotscher},
  journal={The Neuroscientist},
  year={2010},
  volume={16},
  pages={421 - 434}
}
Neuronal migration is an essential step of brain development and is controlled by a variety of cellular proteins and extracellular matrix molecules. Reelin, an extracellular matrix protein, is required for neuronal migration. Over the past 10 years, the Reelin signaling cascade has been studied intensively. However, the role of Reelin in neuronal migration has remained unclear. Different Reelin fragments and different Reelin receptors suggest multiple functions of Reelin. In this review, the… 
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It is suggested that Reelin induces branching of the leading processes of migrating neurons and that of basal processes of RGCs when they arrive at the Reelin-containing marginal zone and may be crucial for the termination of nuclear translocation during the migratory process and for correct neuronal positioning.
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TLDR
Results indicate that Reelin-induced phosphorylation of cofilin is an important component in the orientation and directed migration of cortical neurons and in their correct lamination.
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In utero electroporation coupled with real-time imaging reveals that actin cytoskeleton dynamics during neuronal migration are controlled by the cooperation of reelin and cofilin.
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The data strongly suggest that Reelin has a dual role in NB, where autocrine expression marks low-grade differentiating tumour cells, whereas paracrine Reelin presented by LECs and BECs may act as a chemoattractant and promote hematogenic and lymphogenic dissemination in progressed stages.
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