GnaqM1J: An ENU induced mutant allele affecting pigmentation in the mouse

Over the last decade, large-scale, primarily ENU based, chemical mutagenesis projects (Clark et al, 2004) inspired the development of high-throughput, broad coverage means to analyze mutant mouse phenotypes. The dark skin mutations, GnaqMhdadsk1 and GnaqMhdadsk10, arose in just such an ENU mutagenesis screen. These dark skin mutations are due to missense… CONTINUE READING