GnRH receptors in cancer: from cell biology to novel targeted therapeutic strategies.


The crucial role of pituitary GnRH receptors (GnRH-R) in the control of reproductive functions is well established. These receptors are the target of GnRH agonists (through receptor desensitization) and antagonists (through receptor blockade) for the treatment of steroid-dependent pathologies, including hormone-dependent tumors. It has also become… (More)
DOI: 10.1210/er.2012-1014