GnRH actions on rat preovulatory follicles are mediated by paracrine EGF-like factors.

@article{Motola2006GnRHAO,
  title={GnRH actions on rat preovulatory follicles are mediated by paracrine EGF-like factors.},
  author={Shmulik Motola and Xiumei Cao and Helena Ashkenazi and Malka Popliker and Alex Tsafriri},
  journal={Molecular reproduction and development},
  year={2006},
  volume={73 10},
  pages={1271-6}
}
Gonadotropin releasing hormone (GnRH) has been shown to mimic the actions of LH/hCG on oocyte maturation and ovulation. Recent studies demonstrated that induction of ovulation by LH/hCG is mediated, at least in part, by transactivation of epidermal growth factor receptors (EGFR) by autocrine/paracrine EGF-like factors activated by metalloproteases. Here we have examined whether the action of GnRH on the preovulatory follicles is exerted through similar mechanisms involving activation of EGFR… CONTINUE READING

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