Glypican-3-targeted 89Zr PET imaging of hepatocellular carcinoma.

@article{Sham2014Glypican3targeted8P,
  title={Glypican-3-targeted 89Zr PET imaging of hepatocellular carcinoma.},
  author={Jonathan Ghing Chi Sham and Forrest M Kievit and J. R. Grierson and Robert S. Miyaoka and Matthew M Yeh and Miqin Zhang and Raymond Yeung and Satoshi Minoshima and James Park},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={2014},
  volume={55 5},
  pages={
          799-804
        }
}
UNLABELLED Hepatocellular carcinoma (HCC) is a devastating malignancy in which imperfect imaging plays a primary role in diagnosis. Glypican-3 (GPC3) is an HCC-specific cell surface proteoglycan overexpressed in most HCCs. This paper presents the use of (89)Zr-conjugated monoclonal antibody against GPC3 ((89)Zr-αGPC3) for intrahepatic tumor localization using PET. METHODS Polymerase chain reaction confirmed relative GPC3 expression in cell lines. In vitro binding, in vivo biodistribution, and… CONTINUE READING
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