Glypican-3 inhibits Hedgehog signaling during development by competing with patched for Hedgehog binding.

@article{Capurro2008Glypican3IH,
  title={Glypican-3 inhibits Hedgehog signaling during development by competing with patched for Hedgehog binding.},
  author={Mariana Isabel Capurro and Ping Xu and Wen Shi and Fuchuan Li and Angela Y. Jia and Jorge Filmus},
  journal={Developmental cell},
  year={2008},
  volume={14 5},
  pages={700-11}
}
Loss-of-function mutations in glypican-3 (GPC3), one of the six mammalian glypicans, causes the Simpson-Golabi-Behmel overgrowth syndrome (SGBS), and GPC3 null mice display developmental overgrowth. Because the Hedgehog signaling pathway positively regulates body size, we hypothesized that GPC3 acts as an inhibitor of Hedgehog activity during development. Here, we show that GPC3 null embryos display increased Hedgehog signaling and that GPC3 inhibits Hedgehog activity in cultured mouse… CONTINUE READING
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