Glypican-3 as an emerging molecular target for hepatocellular carcinoma gene therapy

@article{Yao2014Glypican3AA,
  title={Glypican-3 as an emerging molecular target for hepatocellular carcinoma gene therapy},
  author={Min Yao and Li Wang and Zhizhen Dong and Qi Feng Qian and Yun Peng Shi and Dandan Yu and Shiye Wang and Wenjie Zheng and Dengfu Yao},
  journal={Tumor Biology},
  year={2014},
  volume={35},
  pages={5857-5868}
}
Glypican-3 (GPC-3), a membrane-associated heparan sulfate proteoglycan, plays a crucial role in cell proliferation and metastasis, particularly in hepatocellular carcinoma (HCC) progression, and perhaps is a valuable target for its gene therapy. However, its mechanism remains to be explored. In the present study, the biological behaviors of HCC cells were investigated by interfering GPC-3 gene transcription. After the cells were transfected with specific GPC-3 short hairpin RNA (shRNA), the… CONTINUE READING
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