Glypican-1 controls brain size through regulation of fibroblast growth factor signaling in early neurogenesis

@article{Jen2009Glypican1CB,
  title={Glypican-1 controls brain size through regulation of fibroblast growth factor signaling in early neurogenesis},
  author={Yi-Huei Linda Jen and Michele Musacchio and Arthur D. Lander},
  journal={Neural Development},
  year={2009},
  volume={4},
  pages={33 - 33}
}
Cell surface heparan sulfate proteoglycans (HSPGs) act as co-receptors for multiple families of growth factors that regulate animal cell proliferation, differentiation and patterning. Elimination of heparan sulfate during brain development is known to produce severe structural abnormalities. Here we investigate the developmental role played by one particular HSPG, glypican-1 (Gpc1), which is especially abundant on neuronal cell membranes, and is the major HSPG of the adult rodent brain. Mice… CONTINUE READING
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