Glypican-1 Mediates Both Prion Protein Lipid Raft Association and Disease Isoform Formation

@inproceedings{Taylor2009Glypican1MB,
  title={Glypican-1 Mediates Both Prion Protein Lipid Raft Association and Disease Isoform Formation},
  author={David R. Taylor and Isobel J. Whitehouse and Nigel M Hooper},
  booktitle={PLoS pathogens},
  year={2009}
}
In prion diseases, the cellular form of the prion protein, PrP(C), undergoes a conformational conversion to the infectious isoform, PrP(Sc). PrP(C) associates with lipid rafts through its glycosyl-phosphatidylinositol (GPI) anchor and a region in its N-terminal domain which also binds to heparan sulfate proteoglycans (HSPGs). We show that heparin displaces… CONTINUE READING
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