Glyphosate-Based Herbicides Potently Affect Cardiovascular System in Mammals: Review of the Literature

@article{Gress2014GlyphosateBasedHP,
  title={Glyphosate-Based Herbicides Potently Affect Cardiovascular System in Mammals: Review of the Literature},
  author={Steeve Gress and Sandrine Lemoine and Gilles Eric S{\'e}ralini and Paolo Emilio Puddu},
  journal={Cardiovascular Toxicology},
  year={2014},
  volume={15},
  pages={117-126}
}
In glyphosate (G)-based herbicides (GBHs), the declared active principle G is mixed with several adjuvants that help it to penetrate the plants’ cell membranes and its stabilization and liposolubility. Its utilization is growing with genetically modified organisms engineered to tolerate GBH. Millions of farmers suffer poisoning and death in developing countries, and occupational exposures and suicide make GBH toxicity a worldwide concern. As GBH is found in human plasma, widespread hospital… 
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46 Citations
Highly Influential Citations
3
Background Citations
20
Methods Citations
2
Results Citations
2

46 Citations

Cardiotoxic Electrophysiological Effects of the Herbicide Roundup® in Rat and Rabbit Ventricular Myocardium In Vitro
TLDR
The action potential prolonging effect of R pointing to ICa interference might explain both conduction blocks and proarrhythmia in vitro and may well be causative of QT prolongation, atrioventricular conduction Blocks and arrhythmias in man after GBH acute intoxications as reported in retrospective hospital records.
Electrocardiographic abnormalities associated with acute glyphosate toxicity
Cardiovascular damage associated with subchronic exposure to the glyphosate herbicide in Wistar rats
TLDR
The study suggests that glyphosate has atherogenic potential, regardless of the concentration and route of exposure, and fatty streaks were observed in most animals exposed to glyphosate and were more prevalent in male rats.
Glyphosate Caused Detrimental Changes in Enzymatic Antioxidants in Rats
TLDR
Glyphosate has induced oxidative stress in experimental animals by decreasing the expression of Enzymatic Antioxidants.
Dig1 protects against locomotor and biochemical dysfunctions provoked by Roundup
TLDR
D, without any side effect observable in these conditions, presented strong preventive and therapeutic properties in vivo after a short-term intoxication by the widely used pesticide Roundup.
Glyphosate-based herbicides and oxidative stress
Glyphosate exposure, cardiovascular diseases and cancer risks
TLDR
Current epidemiology evidence is insufficient to conclude that exposure to GLY increases the risk of cardiovascular disease and or non-Hodgkin lymphoma, or any other type of cancer.
The Herbicide Glyphosate and Its Apparently Controversial Effect on Human Health: An Updated Clinical Perspective.
TLDR
The controversy about the dangers of the product for human beings is untangled in view of a very recent development, when the so -called Monsanto Papers came to light, revealing a coordinated strategy to manipulate the debate about the safety of glyphosate to the company's advantage.
Potential toxic effects of glyphosate and its commercial formulations below regulatory limits.
Antioxidant and cytoprotective effects of N-acetylcysteine against subchronic oral glyphosate-based herbicide-induced oxidative stress in rats
TLDR
It was concluded that NAC protects oxidative stress and tissue damage induced by GBH in blood and tissue and this prophylactic effect could be attributed to its antioxidant and free radical sweeper character.
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References

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TLDR
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TLDR
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TLDR
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