Glyphosate-Based Herbicides Potently Affect Cardiovascular System in Mammals: Review of the Literature

  title={Glyphosate-Based Herbicides Potently Affect Cardiovascular System in Mammals: Review of the Literature},
  author={Steeve Gress and Sandrine Lemoine and Gilles Eric S{\'e}ralini and Paolo Emilio Puddu},
  journal={Cardiovascular Toxicology},
In glyphosate (G)-based herbicides (GBHs), the declared active principle G is mixed with several adjuvants that help it to penetrate the plants’ cell membranes and its stabilization and liposolubility. Its utilization is growing with genetically modified organisms engineered to tolerate GBH. Millions of farmers suffer poisoning and death in developing countries, and occupational exposures and suicide make GBH toxicity a worldwide concern. As GBH is found in human plasma, widespread hospital… 
Cardiotoxic Electrophysiological Effects of the Herbicide Roundup® in Rat and Rabbit Ventricular Myocardium In Vitro
The action potential prolonging effect of R pointing to ICa interference might explain both conduction blocks and proarrhythmia in vitro and may well be causative of QT prolongation, atrioventricular conduction Blocks and arrhythmias in man after GBH acute intoxications as reported in retrospective hospital records.
Cardiovascular damage associated with subchronic exposure to the glyphosate herbicide in Wistar rats
The study suggests that glyphosate has atherogenic potential, regardless of the concentration and route of exposure, and fatty streaks were observed in most animals exposed to glyphosate and were more prevalent in male rats.
Glyphosate Caused Detrimental Changes in Enzymatic Antioxidants in Rats
Glyphosate has induced oxidative stress in experimental animals by decreasing the expression of Enzymatic Antioxidants.
Dig1 protects against locomotor and biochemical dysfunctions provoked by Roundup
D, without any side effect observable in these conditions, presented strong preventive and therapeutic properties in vivo after a short-term intoxication by the widely used pesticide Roundup.
Glyphosate exposure, cardiovascular diseases and cancer risks
Current epidemiology evidence is insufficient to conclude that exposure to GLY increases the risk of cardiovascular disease and or non-Hodgkin lymphoma, or any other type of cancer.
The Herbicide Glyphosate and Its Apparently Controversial Effect on Human Health: An Updated Clinical Perspective.
The controversy about the dangers of the product for human beings is untangled in view of a very recent development, when the so -called Monsanto Papers came to light, revealing a coordinated strategy to manipulate the debate about the safety of glyphosate to the company's advantage.
Potential toxic effects of glyphosate and its commercial formulations below regulatory limits.
Antioxidant and cytoprotective effects of N-acetylcysteine against subchronic oral glyphosate-based herbicide-induced oxidative stress in rats
It was concluded that NAC protects oxidative stress and tissue damage induced by GBH in blood and tissue and this prophylactic effect could be attributed to its antioxidant and free radical sweeper character.


Surfactant volume is an essential element in human toxicity in acute glyphosate herbicide intoxication
Treatment of patients with acute glyphosate herbicide intoxication should take into account the volume and not the type of surfactants in herbicide formulations, as indicated by the results of this study.
A role for solvents in the toxicity of agricultural organophosphorus pesticides
Clinical presentations and prognostic factors of a glyphosate-surfactant herbicide intoxication: a review of 131 cases.
In managing patients who have larger amount of GlySH ingestion, airway protection, early detection of pulmonary edema, and prevention of further pulmonary damage and renal damage appear to be of critical importance.
[Glyphosate and its formulations--toxicity, occupational and environmental exposure].
Presenting adverse effects of glyphosate and its formulations focused on the role of glyphosate formulations in hormonal disorders by impeding the expression of steroidogenic acute regulatory protein and the inhibition of aromatase activity, and revealed that glyphosate as a phosphonate herbicide does not inhibit directly the activity of acetylcholinesterase.
Rapid lethal intoxication caused by the herbicide glyphosate-trimesium (Touchdown)
It is proposed that containers with glyphosate-trimesium must be labelled because of the apparent effect of lethal intoxication, and it is suggested that the lethal mechanism between the two herbicides may be different.
A prospective observational study of the clinical toxicology of glyphosate-containing herbicides in adults with acute self-poisoning
This prospective observational case series was conducted in two hospitals in Sri Lanka between 2002 and 2007 and found that despite treatment in rural hospitals with limited resources, the mortality was 3.2%, which is lower than that reported in previous case series.
Acute Poisoning with a Glyphosate-Surfactant Herbicide ('Roundup'): A Review of 93 Cases
There were seven deaths following ingestion of 'Roundup' alone, due to a syndrome that involved hypotension, unresponsive to intravenous fluids or vasopressor drugs, and sometimes pulmonary oedema, in the presence of normal central venous pressure.
Glyphosate Poisoning
Experimental studies suggest that the toxicity of the surfactant, polyoxyethyleneamine (POEA), is greater than theoxicity of glyphosate alone and commercial formulations alone and there is insufficient evidence to conclude that glyphosate preparations containing POEA are more toxic than those containing alternative surfactants.