Glyoxalase I overexpression ameliorates renal ischemia-reperfusion injury in rats.

@article{Kumagai2009GlyoxalaseIO,
  title={Glyoxalase I overexpression ameliorates renal ischemia-reperfusion injury in rats.},
  author={Takanori Kumagai and Masaomi Nangaku and Ichiro Kojima and Ryoji Nagai and Julie R. Ingelfinger and Toshio Miyata and Toshiro Fujita and Reiko Inagi},
  journal={American journal of physiology. Renal physiology},
  year={2009},
  volume={296 4},
  pages={F912-21}
}
Methylglyoxal (MG), a highly reactive carbonyl compound generated by carbohydrate oxidation and glycolysis, is the major precursor of protein glycation and induces cytotoxicity leading to apoptosis. Although recent studies have emphasized that MG accumulates in not only chronic oxidative stress-related diseases but also acute hypoxic conditions, the pathogenic contribution of MG in acute diseases is unclear. MG is efficiently metabolized by the glyoxalase system, namely, glyoxalase I. We… CONTINUE READING

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