Glycyrrhizin protects brain against ischemia-reperfusion injury in mice through HMGB1-TLR4-IL-17A signaling pathway.

@article{Zhang2014GlycyrrhizinPB,
  title={Glycyrrhizin protects brain against ischemia-reperfusion injury in mice through HMGB1-TLR4-IL-17A signaling pathway.},
  author={Jiancheng Zhang and Yan Wu and Zelin Weng and Ting Zhou and Tao Feng and Yun Lian Lin},
  journal={Brain research},
  year={2014},
  volume={1582},
  pages={176-86}
}
High mobility group box 1 (HMGB1)-Toll-like receptor 4 (TLR4) signaling has been recently found to induce interleukin (IL)-17A secretion in drug-induced hepatitis and myocardial I/R injury. The purpose of this study is to evaluate whether HMGB1-TLR4 signaling could induce IL-17A secretion and lead to brain I/R injury. We also sought to investigate whether glycyrrhizin elucidated its neuroprotective effects through HMGB1-TLR4-IL-17A signaling pathway. Various biochemical estimations… CONTINUE READING
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