Glycyrrhetinic acid, the active principle of licorice, can reduce the thickness of subcutaneous thigh fat through topical application

@article{Armanini2005GlycyrrhetinicAT,
  title={Glycyrrhetinic acid, the active principle of licorice, can reduce the thickness of subcutaneous thigh fat through topical application},
  author={Decio Armanini and Davide Nacamulli and Francesco Francini-Pesenti and Giuliana Battagin and Eugenio Ragazzi and Cristina Fiore},
  journal={Steroids},
  year={2005},
  volume={70},
  pages={538-542}
}
Cortisol is involved in the distribution and deposition of fat, and its action is regulated by the activity of 11beta-hydroxysteroid dehydrogenase. Glycyrrhetinic acid, the active principle of licorice root, blocks 11beta-hydroxysteroid dehydrogenase type 1, thus reducing the availability of cortisol at the level of adipocytes. We evaluated the effect of topical application of a cream containing glycyrrhetinic acid in the thickness of fat at the level of the thigh. Eighteen healthy women (age… CONTINUE READING
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