Glycyrrhetic acid (a metabolic substance and aglycon of glycyrrhizin) induces apoptosis in human hepatoma, promyelotic leukemia and stomach cancer cells.

@article{Hibasami2006GlycyrrheticA,
  title={Glycyrrhetic acid (a metabolic substance and aglycon of glycyrrhizin) induces apoptosis in human hepatoma, promyelotic leukemia and stomach cancer cells.},
  author={Hiroshige Hibasami and H. Iwase and Kazumi Yoshioka and Hidehisa Takahashi},
  journal={International journal of molecular medicine},
  year={2006},
  volume={17 2},
  pages={
          215-9
        }
}
We have investigated the effect of glycyrrhetic acid (GR) which is metabolic substance of glycyrrhizin, on DNA of human hepatoma (HLE), promyelotic leukemia (HL-60) and stomach cancer (KATO III) cells. GR displayed apoptotic effects against HLE, HL-60 and KATO III cells. The fragmentation of DNA by GR to oligonucleosomal-sized fragments, a characteristic of apoptosis, was dose- and time-dependent in these cell lines. These findings suggest that growth inhibition of these cell lines by GR result… 
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Glycyrrhetinic Acid inhibits cell growth and induces apoptosis in ovarian cancer a2780 cells.
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Isoangustone A present in hexane/ethanol extract of Glycyrrhiza uralensis induces apoptosis in DU145 human prostate cancer cells via the activation of DR4 and intrinsic apoptosis pathway.
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It is demonstrated that the activation of DR4 contributes to HEGU- and isoangustone A-induced apoptosis of DU145 cells.
β-Cyclodextrin/glycyrrhizic acid functionalised quantum dots selectively enter hepatic cells and induce apoptosis.
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β-CD/GA-functionalised QDs have therapeutic potential against cancer and induced apoptosis in hepatocarcinoma cells is suggested.
Synthesis and antitumor activity of ring A modified glycyrrhetinic acid derivatives.
18β-Glycyrrhetinic acid potentiates apoptotic effect of trichostatin A on human epithelial ovarian carcinoma cell lines.
18α-glycyrrhetinic acid targets prostate cancer cells by down-regulating inflammation-related genes.
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The results of this study suggest that AGA may be a promising anticancer agent that merits further investigation for the chemoprevention and treatment of prostate cancer.
Synthesis and biological evaluation of furoxan-based nitric oxide-releasing derivatives of glycyrrhetinic acid as anti-hepatocellular carcinoma agents.
Synthesis and antitumour activity of glycyrrhetinic acid derivatives.
18beta-Glycyrrhetinic acid induces apoptotic cell death in SiHa cells and exhibits a synergistic effect against antibiotic anti-cancer drug toxicity.
Conversions at C‐30 of Glycyrrhetinic Acid and Their Impact on Antitumor Activity
TLDR
The extracts of the roots of licorice have been used in traditional and folk medicine to treat a broad variety of maladies and the main ingredient of these extracts is glycyrrhicinic acid, which has many biological activities, among them a pronounced cytotoxicity against tumor cells.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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