Glycosyltransferase mutants: key to new insights in glycobiology.

  title={Glycosyltransferase mutants: key to new insights in glycobiology.},
  author={Pamela Stanley and Ella Ioffe},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={9 14},
Glycosyltransferases (Glyc-T's) catalyze the synthesis of the carbohydrate portions of glycoproteins, glycolipids, and proteoglycans. Most Glyc-T's transfer one sugar in one linkage and are encoded by a unique gene. Thus, synthesis of a branched carbohydrate may require expression of at least 30 Glyc-T genes. Mutations that alter Glyc-T activity therefore provide an approach to identifying functions for carbohydrates. These fall into two general categories: 1) intramolecular functions… CONTINUE READING
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