Glycosylphosphatidylinositol anchors of membrane glycoproteins are binding determinants for the channel-forming toxin aerolysin.

@article{Diep1998GlycosylphosphatidylinositolAO,
  title={Glycosylphosphatidylinositol anchors of membrane glycoproteins are binding determinants for the channel-forming toxin aerolysin.},
  author={Dzung Bao Diep and Kathryn L Nelson and Srikumar M. Raja and E N Pleshak and J. Thomas Buckley},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 4},
  pages={2355-60}
}
Cells that are sensitive to the channel-forming toxin aerolysin contain surface glycoproteins that bind the toxin with high affinity. Here we show that a common feature of aerolysin receptors is the presence of a glycosylphosphatidylinositol anchor, and we present evidence that the anchor itself is an essential part of the toxin binding determinant. The glycosylphosphatidylinositol (GPI)-anchored T-lymphocyte protein Thy-1 is an example of a protein that acts as an aerolysin receptor. This… CONTINUE READING