Glycosylphosphatidylinositol-anchored proteases of Candida albicans target proteins necessary for both cellular processes and host-pathogen interactions.

@article{Albrecht2006Glycosylphosphatidylinositolancho,
  title={Glycosylphosphatidylinositol-anchored proteases of Candida albicans target proteins necessary for both cellular processes and host-pathogen interactions.},
  author={Antje Albrecht and Angelika Felk and Iva Pichov{\'a} and Julian R Naglik and Martin Schaller and Piet Hein S de Groot and Donna M MacCallum and Frank C. Odds and Wilhelm Sch{\"a}fer and F. M. Klis and Monod Michel and Bernhard Hube},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 2},
  pages={688-94}
}
Intracellular and secreted proteases fulfill multiple functions in microorganisms. In pathogenic microorganisms extracellular proteases may be adapted to interactions with host cells. Here we describe two cell surface-associated aspartic proteases, Sap9 and Sap10, which have structural similarities to yapsins of Saccharomyces cerevisiae and are produced by the human pathogenic yeast Candida albicans. Sap9 and Sap10 are glycosylphosphatidylinositol-anchored and located in the cell membrane or… CONTINUE READING
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GPI-anchored Proteases of Candida albicans 694 JOURNAL OF BIOLOGICAL CHEMISTRY

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