Glycosylation requirements for intracellular transport and function of the hemagglutinin of influenza virus.

@article{Gallagher1992GlycosylationRF,
  title={Glycosylation requirements for intracellular transport and function of the hemagglutinin of influenza virus.},
  author={P. J. Gallagher and J. M. Henneberry and Joseph F. Sambrook and M J Gething},
  journal={Journal of virology},
  year={1992},
  volume={66 12},
  pages={7136-45}
}
The contribution of each of the seven asparagine-linked oligosaccharide side chains on the hemagglutinin of the A/Aichi/68 (X31) strain of influenza virus was assessed with respect to its effect on the folding, intracellular transport, and biological activities of the molecule. Twenty mutant influenza virus hemagglutinins were constructed and expressed, each of which had one or more of the seven glycosylation sites removed. Investigations of these mutant hemagglutinins indicated that (i) no… CONTINUE READING

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