Glycosylation of voltage-gated calcium channels in health and disease.

@article{Lazniewska2017GlycosylationOV,
  title={Glycosylation of voltage-gated calcium channels in health and disease.},
  author={Joanna Lazniewska and Norbert Weiss},
  journal={Biochimica et biophysica acta. Biomembranes},
  year={2017},
  volume={1859 5},
  pages={
          662-668
        }
}
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It is demonstrated that nonglycosylated hTREK-1 channel subunits are able to reach the cell surface in general but with seemingly reduced efficiency compared to glycosylation-deficient subunits.

Functional identification of potential non-canonical N-glycosylation sites within Cav3.2 T-type calcium channels

Asparagines N345 and N1780 located in the motifs NVC and NPC, respectively, are essential for the expression of the human Ca v 3.2 channel in the plasma membrane and are reported in the first study to report the functional importance of non-canonical N-glycosylation motifs in an ion channel.

Glycosylation of Ī²1 subunit plays a pivotal role in the toxin sensitivity and activation of BK channels

The present study reveals that glycosylation is an indispensable determinant of the modulation of Ī²1-subunit on BK channel pharmacology and its activation, and could lead to the dysfunction of Bk channel, resulting in a pathological state.

Eukaryotic Voltage-Gated Sodium Channels: On Their Origins, Asymmetries, Losses, Diversification and Adaptations

The appearance of voltage-gated, sodium-selective channels with rapid gating kinetics was a limiting factor in the evolution of nervous systems andMulticellularity and the appearance of systems was an impetus for Nav1 channels to adapt to sodium ion selectivity and fast ion gating.

Transcriptional and post-translational regulation of pannexins.

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