Glycosylation of voltage-gated calcium channels in health and disease.

@article{Lazniewska2017GlycosylationOV,
  title={Glycosylation of voltage-gated calcium channels in health and disease.},
  author={Joanna Lazniewska and Norbert Weiss},
  journal={Biochimica et biophysica acta. Biomembranes},
  year={2017},
  volume={1859 5},
  pages={
          662-668
        }
}

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Eukaryotic Voltage-Gated Sodium Channels: On Their Origins, Asymmetries, Losses, Diversification and Adaptations

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References

SHOWING 1-10 OF 122 REFERENCES

The "sweet" side of ion channels.

The discovery of detailed mechanisms of regulation of ions channels by glycosylation provides new insights in the physiology of ion channels and may allow developing new pharmaceutics for the treatment of ion channel-related disorders.

Modulation of Cav3.2 T-type calcium channel permeability by asparagine-linked glycosylation

Data suggest that modulation of N-linked glycosylation of hCav3.2 channels may play an important physiological role, and could also support the alteration of T-type currents observed in disease states.

G Protein Regulation of Neuronal Calcium Channels: Back to the Future

This study revisits this particular regulation and explores new considerations regarding the molecular and cellular mechanisms of direct G protein inhibition of voltage-gated calcium channels.

Phosphorylation of the Cav3.2 T-type calcium channel directly regulates its gating properties

It is shown for the first time, to the knowledge, that Cav3.2 channels are highly phosphorylated in the mammalian brain and phosphorylation is established as an important mechanism involved in the dynamic regulation of Cav 3.2 channel gating properties.

Auxiliary subunits: essential components of the voltage-gated calcium channel complex

Calcium channel auxiliary α2δ and β subunits: trafficking and one step beyond

The aim of this Review is to examine both the classic and novel roles for these auxiliary subunits in voltage-gated calcium channel function and beyond.

Voltage-gated calcium channels.

  • W. Catterall
  • Biology
    Cold Spring Harbor perspectives in biology
  • 2011
The molecular relationships and physiological functions of these voltage-gated Ca(2+) channel proteins are presented and information on their molecular, genetic, physiological, and pharmacological properties is provided.
...