Glycosylation of the osmoresponsive transient receptor potential channel TRPV4 on Asn-651 influences membrane trafficking.

@article{Xu2006GlycosylationOT,
  title={Glycosylation of the osmoresponsive transient receptor potential channel TRPV4 on Asn-651 influences membrane trafficking.},
  author={Hongshi Xu and Yi Fu and Wei Tian and David Md Mph Cohen},
  journal={American journal of physiology. Renal physiology},
  year={2006},
  volume={290 5},
  pages={
          F1103-9
        }
}
We identified a consensus N-linked glycosylation motif within the pore-forming loop between the fifth and sixth transmembrane segments of the osmoresponsive transient receptor potential (TRP) channel TRPV4. Mutation of this residue from Asn to Gln (i.e., TRPV4(N651Q)) resulted in loss of a slower migrating band on anti-TRPV4 immunoblots and a marked reduction in lectin-precipitable TRPV4 immunoreactivity. HEK293 cells transiently transfected with the mutant TRPV4(N651Q) exhibited increased… CONTINUE READING

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