Glycosylation of mouse DPP4 plays a role in inhibiting Middle East respiratory syndrome coronavirus infection.

Abstract

Middle East respiratory syndrome coronavirus (MERS-CoV) utilizes dipeptidyl peptidase 4 (DPP4) as an entry receptor. Mouse DPP4 (mDPP4) does not support MERS-CoV entry; however, changes at positions 288 and 330 can confer permissivity. Position 330 changes the charge and glycosylation state of mDPP4. We show that glycosylation is a major factor impacting… (More)
DOI: 10.1128/JVI.03445-14

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Cite this paper

@article{Peck2015GlycosylationOM, title={Glycosylation of mouse DPP4 plays a role in inhibiting Middle East respiratory syndrome coronavirus infection.}, author={Kayla M Peck and Adam S. Cockrell and Boyd L. Yount and Trevor D. Scobey and Ralph S. Baric and Mark T. Heise}, journal={Journal of virology}, year={2015}, volume={89 8}, pages={4696-9} }