Glycosylation of minor envelope glycoproteins of porcine reproductive and respiratory syndrome virus in infectious virus recovery, receptor interaction, and immune response.

@article{Das2011GlycosylationOM,
  title={Glycosylation of minor envelope glycoproteins of porcine reproductive and respiratory syndrome virus in infectious virus recovery, receptor interaction, and immune response.},
  author={Phani B. Das and Hiep L. X. Vu and Phat X. Dinh and Jonathan L Cooney and Byungjoon Kwon and Fernando A. Osorio and Asit K. Pattnaik},
  journal={Virology},
  year={2011},
  volume={410 2},
  pages={385-94}
}
The role of N-glycosylation of the three minor envelope glycoproteins (GP2, GP3, and GP4) of porcine reproductive and respiratory syndrome virus (PRRSV) on infectious virus production, interactions with the receptor CD163, and neutralizing antibody production in infected pigs was examined. By mutation of the glycosylation sites in these proteins, the studies show that glycan addition at N184 of GP2, N42, N50 and N131 of GP3 is necessary for infectious virus production. Although single-site… CONTINUE READING