Glycosylation of liver acute-phase proteins in pancreatic cancer and chronic pancreatitis.

@article{Sarrats2010GlycosylationOL,
  title={Glycosylation of liver acute-phase proteins in pancreatic cancer and chronic pancreatitis.},
  author={Ariadna Sarrats and Radka Saldova and Eva Pla and Esther Fort and David J. Harvey and Weston B. Struwe and Rafael de Llorens and Pauline M. Rudd and Ram{\'o}n Peracaula},
  journal={Proteomics. Clinical applications},
  year={2010},
  volume={4 4},
  pages={
          432-48
        }
}
PURPOSE Glycosylation of acute-phase proteins (APP), which is partially regulated by cytokines, may be distinct in disease and provide useful tumour markers. Thus, we have examined the glycosylation of major serum APP in pancreatic cancer (PaC), chronic pancreatitis (CP) and control patients. EXPERIMENTAL DESIGN Using a specific anti-sialyl Lewis X antibody and N-glycan sequencing, we have determined glycosylation changes on α-1-acid glycoprotein (AGP), haptoglobin (HPT), fetuin (FET), α-1… CONTINUE READING
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