Glycosylation of human IgG-Fc: influences on structure revealed by differential scanning micro-calorimetry.

@article{Ghirlando1999GlycosylationOH,
  title={Glycosylation of human IgG-Fc: influences on structure revealed by differential scanning micro-calorimetry.},
  author={Rodolfo Ghirlando and John N Lund and Margaret D Goodall and Royston Jefferis},
  journal={Immunology letters},
  year={1999},
  volume={68 1},
  pages={47-52}
}
Glycosylation of the Fc region of IgG (IgG-Fc) is essential for the full expression of Fc effector functions. The profound differences in functional activity observed between glycosylated and aglycosylated IgG have not previously been paralleled by the demonstration of large-scale structural changes. In the present study differential scanning microcalorimetry (DSMC) was used to investigate IgG-Fc glycoprotein stability and to determine the thermodynamic parameters for thermal unfolding, which… CONTINUE READING

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