Glycosylation of fluoroquinolones through direct and oxygenated polymethylene linkages as a sugar-mediated active transport system for antimicrobials.

Abstract

We report herein the synthesis and biological testing of several glycosylated derivatives of some fluoroquinolone antibiotics. In particular, we have prepared several glycosylated derivatives of ciprofloxacin (2) in which the carbohydrate units are linked to the free secondary amine of the piperazine unit by: (a) no linker (e.g., a glycosylamine), (b) a… (More)

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@article{Jung1999GlycosylationOF, title={Glycosylation of fluoroquinolones through direct and oxygenated polymethylene linkages as a sugar-mediated active transport system for antimicrobials.}, author={Michael E. Jung and Eun Chan Yang and Binh Thai Vu and Mehrak Kiankarimi and Elias Spyrou and Jonathan D Kaunitz}, journal={Journal of medicinal chemistry}, year={1999}, volume={42 19}, pages={3899-909} }