Glycosylation of IgA1 and pathogenesis of IgA nephropathy

Abstract

IgA nephropathy, described in 1968 as IgA-IgG immune-complex disease, is an autoimmune disease. Galactose-deficient IgA1 is recognized by unique autoantibodies, resulting in the formation of pathogenic immune complexes that ultimately induce glomerular injury. Thus, formation of the galactose-deficient IgA1-containing immune complexes is a critical factor… (More)
DOI: 10.1007/s00281-012-0306-z

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