Glycosylation modulates cardiac excitability by altering voltage-gated potassium currents

@inproceedings{Schwetz2009GlycosylationMC,
  title={Glycosylation modulates cardiac excitability by altering voltage-gated potassium currents},
  author={Tara A. Schwetz},
  year={2009}
}
Neuronal, cardiac, and skeletal muscle electrical signaling is achieved through the highly regulated activity of several types of voltage-gated ion channels to produce an action potential (AP). Voltage-gated potassium (Kv) channels are responsible for repolarization of the AP. Kv channels are uniquely and heavily glycosylated proteins. Previous reports indicate glycosylation modulates gating of some Kv channel isoforms; often, terminal sialic acid residues alter Kv channel gating. Here, we… CONTINUE READING

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