Glycosylation-dependent interactions of C-type lectin DC-SIGN with colorectal tumor-associated Lewis glycans impair the function and differentiation of monocyte-derived dendritic cells.

@article{Nonaka2008GlycosylationdependentIO,
  title={Glycosylation-dependent interactions of C-type lectin DC-SIGN with colorectal tumor-associated Lewis glycans impair the function and differentiation of monocyte-derived dendritic cells.},
  author={Motohiro Nonaka and Bruce Yong Ma and Ryuuya Murai and Natsuko Nakamura and Makoto Baba and Nobuko Kawasaki and Keiko Hodohara and Shinji Asano and Toshisuke Kawasaki},
  journal={Journal of immunology},
  year={2008},
  volume={180 5},
  pages={3347-56}
}
Dendritic cells (DCs) are APCs that play an essential role by bridging innate and adaptive immunity. DC-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN) is one of the major C-type lectins expressed on DCs and exhibits high affinity for nonsialylated Lewis (Le) glycans. Recently, we reported the characterization of oligosaccharide ligands expressed on SW1116, a typical human colorectal carcinoma recognized by mannan-binding protein, which is a serum C-type lectin and has… CONTINUE READING