Glycosylation as a strategy to improve antibody-based therapeutics

@article{Jefferis2009GlycosylationAA,
  title={Glycosylation as a strategy to improve antibody-based therapeutics},
  author={Royston Jefferis},
  journal={Nature Reviews Drug Discovery},
  year={2009},
  volume={8},
  pages={226-234}
}
To date, more than 20 recombinant immunoglobulin G (IgG) antibody therapeutics are licensed for the treatment of various diseases. The mechanism of action of recombinant monoclonal antibodies (rMAbs) has been extensively investigated and several distinct pathways have been defined; selective activation of specific pathways may optimize clinical outcomes for different diseases, such as cancer and chronic inflammation. Human IgG is a glycoprotein with oligosaccharides attached at a single site… CONTINUE READING
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