Glycosylation allows cell-surface transport of an anchored secretory protein.

@article{Guan1985GlycosylationAC,
  title={Glycosylation allows cell-surface transport of an anchored secretory protein.},
  author={Jun-Lin Guan and Carolyn E. Machamer and John K. Rose},
  journal={Cell},
  year={1985},
  volume={42 2},
  pages={489-96}
}
We have previously described the construction and expression of a hybrid gene encoding a membrane-anchored form of rat growth hormone. This protein is anchored in cellular membranes by a carboxy-terminal extension composed of the transmembrane and cytoplasmic domains of the vesicular stomatitis virus glycoprotein. The protein is transported efficiently to the Golgi apparatus but not to the cell surface. To examine the possibility that N-linked glycosylation might be required for protein… CONTINUE READING