Glycosylation Site for Chondroitin Sulfate on the Neural Part-time Proteoglycan, Neuroglycan C*

@article{Aono2004GlycosylationSF,
  title={Glycosylation Site for Chondroitin Sulfate on the Neural Part-time Proteoglycan, Neuroglycan C*},
  author={Sachiko Aono and Yoshihito Tokita and Takuya Shuo and Shinobu Yamauchi and Fumiko Matsui and Keiko Nakanishi and Kanako Hirano and Mamoru Sano and Atsuhiko Oohira},
  journal={Journal of Biological Chemistry},
  year={2004},
  volume={279},
  pages={46536 - 46541}
}
Neuroglycan C (NGC) is a membrane-spanning chondroitin sulfate (CS) proteoglycan that is expressed predominantly in the central nervous system (CNS). NGC dramatically changed its structure from a proteoglycan to a nonproteoglycan form with cerebellar development, whereas a small portion of NGC molecules existed in a nonproteoglycan form in the other areas of the mature CNS, suggesting that the CS glycosylation of NGC is developmentally regulated in the whole CNS. As primary cultured neurons and… 
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Chondroitin sulfate proteoglycans in the brain.
Neuroglycan C, A Brain-Specific Chondroitin Sulfate Proteoglycan, Interacts with Pleiotrophin, A Heparin-Binding Growth Factor
TLDR
Results suggest that NGC interacts with PTN, and pleiotrophin bound to both chondroitin sulfate-bearing NGC and chONDroitinase-treated NGC prepared from the neonatal rat brain.
Neuroglycan C Is a Novel Midkine Receptor Involved in Process Elongation of Oligodendroglial Precursor-like Cells*
TLDR
It is concluded that neuroglycan C is a novel component of midkine receptors involved in process elongation in undifferentiated bipolar CG-4 cells.
Expression and identification of a new splice variant of neuroglycan C, a transmembrane chondroitin sulfate proteoglycan, in the human brain
TLDR
The expression of NGC in the human brain, mainly in the hippocampus, was studied and some observations were confirmed by conducting experiments using rat brain, and NGC‐IV, which was first found in the present study, had the shortest cytoplasmic domain among the four variants.
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TLDR
Recent data in relation to previous knowledge of core proteins and GAG-attachment sites in Chn and CS proteoglycans of C.elegans are discussed, indicating that specialization of proteoglycan-mediated functions may have evolved early in metazoan evolution.
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This review discusses recent evidence suggesting GAGs have specific roles in neuronal patterning and synaptogenesis, and considers the function of proteoglycan core proteins in these processes, stressing their likely role as co‐receptors of different signaling pathways in a redundant and context‐dependent manner.
Differential neuroglycan C expression during retinal degeneration in Rpe65−/− mice
TLDR
During retinal degeneration in Rpe65−/− mice, NGC expression is induced in the neural retina, but not in the RPE, where NGC is expressed at highest levels.
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