Glycosylation Is Dispensable for Sorting of Synaptotagmin 1 but Is Critical for Targeting of SV2 and Synaptophysin to Recycling Synaptic Vesicles*

@article{Kwon2012GlycosylationID,
  title={Glycosylation Is Dispensable for Sorting of Synaptotagmin 1 but Is Critical for Targeting of SV2 and Synaptophysin to Recycling Synaptic Vesicles*},
  author={Sung E. Kwon and Edwin R. Chapman},
  journal={The Journal of Biological Chemistry},
  year={2012},
  volume={287},
  pages={35658 - 35668}
}
Background: Whether glycosylation is essential for targeting of synaptic vesicle proteins is unclear. Results: Glycosylation-deficient synaptotagmin 1 is correctly targeted and functions normally whereas trafficking of SV2 and synaptophysin is severely affected by the loss of glycosylation. Conclusion: Glycosylation is of differential importance for different synaptic vesicle proteins. Significance: This represents the first quantitative comparison of the trafficking of wild-type and mutant… Expand
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