Glycosylation Focuses Sequence Variation in the Influenza A Virus H1 Hemagglutinin Globular Domain

@inproceedings{Das2010GlycosylationFS,
  title={Glycosylation Focuses Sequence Variation in the Influenza A Virus H1 Hemagglutinin Globular Domain},
  author={Suman R Das and Pere Puigb{\`o} and Scott E Hensley and Darrell E. Hurt and Jack R. Bennink and Jonathan W Yewdell},
  booktitle={PLoS pathogens},
  year={2010}
}
Antigenic drift in the influenza A virus hemagglutinin (HA) is responsible for seasonal reformulation of influenza vaccines. Here, we address an important and largely overlooked issue in antigenic drift: how does the number and location of glycosylation sites affect HA evolution in man? We analyzed the glycosylation status of all full-length H1 subtype HA sequences available in the NCBI influenza database. We devised the "flow index" (FI), a simple algorithm that calculates the tendency for… CONTINUE READING