Glycosylation: heterogeneity and the 3D structure of proteins.

  title={Glycosylation: heterogeneity and the 3D structure of proteins.},
  author={Pauline M. Rudd and Raymond A. Dwek},
  journal={Critical reviews in biochemistry and molecular biology},
  volume={32 1},
Glycoproteins generally exist as populations of glycosylated variants (glycoforms) of a single polypeptide. Although the same glycosylation machinery is available to all proteins that enter the secretory pathway in a given cell, most glycoproteins emerge with characteristic glycosylation patterns and heterogeneous populations of glycans at each glycosylation site. The factors that control the composition of the glycoform populations and the role that heterogeneity plays in the function of… CONTINUE READING
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