Glycosylated tetrahydrosalens as multifunctional molecules for Alzheimer's therapy.

@article{Storr2009GlycosylatedTA,
  title={Glycosylated tetrahydrosalens as multifunctional molecules for Alzheimer's therapy.},
  author={Tim Storr and Lauren E Scott and Meryn L Bowen and David Green and Katherine H. Thompson and Harvey J Schugar and Chris Orvig},
  journal={Dalton transactions},
  year={2009},
  volume={16},
  pages={3034-43}
}
The tetrahydrosalens N,N'-bis(2-hydroxybenzyl)-ethane-1,2-diamine ((2)(1)), N,N'-bis(2-hydroxybenzyl)-(-)-1,2-cyclohexane-(1R,2R)-diamine ((2)(2)), N,N'-bis(2-hydroxybenzyl)-N,N'-dimethyl-ethane-1,2-diamine ((2)(3)), N,N'-bis(2-hydroxybenzyl)-N,N'-dibenzyl-ethane-1,2-diamine ((2)(4)), and N,N'-bis(2-(4-tert-butyl)hydroxybenzyl)-ethane-1,2-diamine ((2)(5)), as well as their prodrug glycosylated forms, (1-5), have been prepared and evaluated in vitro for their potential use as Alzheimer's disease… CONTINUE READING