Glycosylated serum proteins and glycosylated haemoglobin in normal pregnancy.


Glycosylated haemoglobin (HbA1) and glycosylated serum protein concentrations (fructosamine) were monitored in 162 normal pregnancies. The response to the standard 75 g oral glucose tolerance test (OGTT) was used to exclude gestational diabetes. A significant increase in glucose intolerance, measured from the area under the OGTT-curve (r = 0.29, P less than 0.0005) and a highly significant decrease in serum albumin concentration (r = -0.79, P less than 0.0005) due to the redistribution of body water, as occurs during pregnancy, resulted in a statistically significant decrease in serum fructosamine concentration (r = -0.23, P less than 0.01) when related to gestational age in weeks.


Citations per Year

699 Citations

Semantic Scholar estimates that this publication has 699 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{DieijenVisser1986GlycosylatedSP, title={Glycosylated serum proteins and glycosylated haemoglobin in normal pregnancy.}, author={Marja P. van Dieijen-Visser and Tom H B Salemans and Jan W J van Wersch and Louis A. Schellekens and Paul J. Brombacher}, journal={Annals of clinical biochemistry}, year={1986}, volume={23 ( Pt 6)}, pages={661-6} }