Glycosyl-phosphatidylinositol anchored membrane enzymes.

  title={Glycosyl-phosphatidylinositol anchored membrane enzymes.},
  author={Nigel M Hooper},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  volume={266 1},
  • Nigel M Hooper
  • Published 1997 in
    Clinica chimica acta; international journal of…
Several mammalian enzymes are anchored to the outer surface of the plasma membrane by a covalently attached glycosyl-phosphatidylinositol (GPI) structure. These include acetylcholinesterase, alkaline phosphatase, membrane dipeptidase and 5'-nucleotidase. All GPI anchors determined to date have the conserved core structure ethanolamine-PO4-6Man alpha 1-2Man alpha 1-6Man alpha 1-4GlcNH2 alpha 1-6myo-inositol-1-PO4- lipid. In most mammalian GPI anchors the lipid is 1-alkyl-2-acyl-glycerol… CONTINUE READING
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