Glycosyl-phosphatidylinositol: a versatile anchor for cell surface proteins.

  title={Glycosyl-phosphatidylinositol: a versatile anchor for cell surface proteins.},
  author={Martin G. Low},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={3 5},
  • Martin G. Low
  • Published 1989 in
    FASEB journal : official publication of the…
Covalent linkage of proteins to glycosyl-phosphatidylinositol (GPI) molecules is now recognized as an important mechanism for anchoring proteins to membranes. Recent structural work on the GPI anchors indicates that the structure of the glycan connecting the protein and the phosphatidylinositol molecule has been conserved during evolution. Attachment of the protein to the GPI molecule is directed by a signal sequence at the COOH terminus of the polypeptide that is removed during the attachment… CONTINUE READING
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