Glycosphingolipids in cellular interaction, differentiation, and oncogenesis.

@article{Hakomori1981GlycosphingolipidsIC,
  title={Glycosphingolipids in cellular interaction, differentiation, and oncogenesis.},
  author={S. Hakomori},
  journal={Annual review of biochemistry},
  year={1981},
  volume={50},
  pages={
          733-64
        }
}
  • S. Hakomori
  • Published 1981
  • Chemistry, Medicine
  • Annual review of biochemistry
The idea that glycosphingolipids (or, briefly, glycolipids) are ubiquitous components of plasma membrane and display cell type-specific patterns perhaps stemmed from the classical studies on glycolipids of erythrocyte membranes.(1,2) Subsequently, plasma membranes of various animal cells were successfully isolated and analyzed; all were characterized by their much higher content of glycolipid than was found in intracellular membranes.(3–8) It is generally assumed that glycolipids are present at… Expand
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