Glycosphingolipid profile of the apical pole of human placental capillaries: the relevancy of the observed data to Fabry disease.

@article{Hlkov2012GlycosphingolipidPO,
  title={Glycosphingolipid profile of the apical pole of human placental capillaries: the relevancy of the observed data to Fabry disease.},
  author={Helena Hůlkov{\'a} and Jana Ledvinov{\'a} and Ladislav Kuchař and Franti{\vs}ek {\vS}m{\'i}d and Jitka Honz{\'i}kov{\'a} and Milan Elleder},
  journal={Glycobiology},
  year={2012},
  volume={22 5},
  pages={
          725-32
        }
}
A series of six full-term placentas and umbilical cords were examined using the in situ detection of globotriaosylceramide (Gb3Cer), GM1 ganglioside (GM1), GM3 ganglioside (GM3), cholesterol and caveolin 1. Immunohistochemical study showed uniform distinct staining of the apical membrane of villous capillary endothelial cells for Gb3Cer, GM1, GM3 and cholesterol. There was also a strong signal for caveolin 1. The immunophenotype suggests the presence of caveola-associated raft microdomains. The… CONTINUE READING
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