• Corpus ID: 20374762

Glycosome-associated tyrosine-phosphorylated protein in Trypanosoma brucei.

@article{WheelerAlm1993GlycosomeassociatedTP,
  title={Glycosome-associated tyrosine-phosphorylated protein in Trypanosoma brucei.},
  author={E Wheeler-Alm and Stuart Z. Shapiro},
  journal={Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit},
  year={1993},
  volume={44 4},
  pages={
          281-4
        }
}
  • E. Wheeler-Alm, S. Z. Shapiro
  • Published 1 December 1993
  • Biology
  • Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit
Phosphorylation of protein at tyrosine residues is an important mechanism for regulating protein function in eukaryotic cells. In this report we have identified by immunoblotting the target for tyrosine phosphorylation in the protozoan parasite Trypanosoma brucei as a doublet band of protein with molecular masses of 200 and 220 kDa. Ultrastructurally, the tyrosine-phosphorylated protein was localized to the microbody-like organelles unique to kinetoplastid protozoa, called glycosomes…