Glycosaminoglycan therapy prevents TGF-beta1 overexpression and pathologic changes in renal tissue of long-term diabetic rats.

@article{Ceol2000GlycosaminoglycanTP,
  title={Glycosaminoglycan therapy prevents TGF-beta1 overexpression and pathologic changes in renal tissue of long-term diabetic rats.},
  author={Monica Ceol and Giovanni Gambaro and Ulrich Sauer and Bruno Baggio and Franca Anglani and Monica Forino and Sonia Facchin and Luciana Bordin and Cora Weigert and Andreas Nerlich and Erwin D. Schleicher},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2000},
  volume={11 12},
  pages={
          2324-36
        }
}
Chronic induction of the prosclerotic cytokine transforming growth factor beta (TGF-beta) has been implicated in the pathogenesis of diabetic nephropathy. In a rat model of diabetes mellitus-induced glomerulosclerosis, daily administration of a modified heparin (mH) glycosaminoglycan (GAG) preparation with low anticoagulant activity prevented glomerular and tubular matrix accumulation, as well as overexpression of TGF-beta1 mRNA and albuminuria, without obvious side effects. To elucidate the… CONTINUE READING
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