Glycosaminoglycan-targeted fixation for improved bioprosthetic heart valve stabilization.

@article{Mercuri2007GlycosaminoglycantargetedFF,
  title={Glycosaminoglycan-targeted fixation for improved bioprosthetic heart valve stabilization.},
  author={Jeremy Mercuri and Joshua J Lovekamp and Dan Teodor Simionescu and Narendra R Vyavahare},
  journal={Biomaterials},
  year={2007},
  volume={28 3},
  pages={496-503}
}
Numerous crosslinking chemistries and methodologies have been investigated as alternative fixatives to glutaraldehyde (GLUT) for the stabilization of bioprosthetic heart valves (BHVs). Particular attention has been paid to valve leaflet collagen and elastin stability following fixation. However, the stability of glycosaminoglycans (GAGs), the primary component of the spongiosa layer of the BHV, has been largely overlooked despite recent evidence provided by our group illustrating their… CONTINUE READING
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